A retrospective cohort study of more than 900 prostate cancer patients under active surveillance suggested that low testosterone levels (≤...) may increase the risk of higher-grade progression. The study focused on patients with low-risk prostate cancer. Low testosterone was associated with a higher risk of "extreme" disease progression. These findings come from an observation in MedPage Today. The study confirms the link between low testosterone levels and a more aggressive course of prostate cancer. Patients with low testosterone were more likely to progress to a higher grade tumor. Active surveillance is a common approach in low-risk cases. The results highlight the need to monitor testosterone levels in these patients.[1][2]