The study analyzed 92 Chinese patients with gastroesophageal reflux disease (GERD) and extraesophageal symptoms, where proton pump inhibitors (PPIs) often respond less well. Independent predictors of response to PPI were pathological mean nocturnal baseline impedance index (MNBI, p=0.013, OR=4.93), post-reflux swallow-evoked peristaltic wave index (PSPW, p=0.015, OR=4.026, 95% CI:1.308–12.396), acid exposure time (AET, p=0.017, OR=4.246, 95% CI:1.290–13.982) and typical GERD symptoms (p=0.067, 95% CI:1.057–11.374). The combination of MNBI, PSPW and AET achieved a significantly higher AUC than individual parameters (p<0.05). In patients with normal AET, the combined AUC of MNBI and PSPW was higher than MNBI alone (p<0.001). In patients with only extraesophageal symptoms, MNBI and the combination of the three indices had a higher AUC than AET (p<0.05). MNBI and PSPW serve as independent predictors of PPI response, including patients with normal AET, and their combination increases predictive power.