Peristomal pyoderma gangrenosum (PPG) is a rare and difficult to treat inflammatory skin disease that occurs primarily in people after ostomy surgery.[1] The causes of PPG are complex and include immune system disorders, genetic susceptibility, surgical trauma, and other demographic factors that lead to painful ulcers significantly impairing patients' quality of life.[1] Diagnosis requires a multidisciplinary approach involving clinical examination, histopathological tests and advanced diagnostic criteria.[1] Treatment combines wound care, systemic medications and, in some cases, surgery, with a focus on individual patient needs.[1] Nursing care plays a key role, including advanced ulcer management, pain management, psychological support, nutritional measures, and health education.[1] Future research should focus on identifying specific biomarkers, developing new drugs, and establishing uniform nursing practices to improve treatment outcomes and prevent disease recurrence.[1]