The study examined the use of prehospital whole blood for traumatic bleeding in a randomized controlled trial published in the New England Journal of Medicine (Ahead of Print). Whole blood is administered in the field without the need for cross-checking, homogenous or refrigerated low titer O negative (LTOWB) is preferred for minimal risks. Advantages include rapid improvement of coagulation, aggregation, hemoglobin levels and volume replenishment, which is logistically the easiest compared to separated components. The use of whole blood reduces the number of donors (1 instead of 3 components) and derivatives per 24 hours while excluding traumatic brain damage. It is safe with the same risks of infection transmission as with blood components, including hemolysis, thrombosis or TRALI in 5-30% of donors. Additives in the separated components dilute hemoglobin, coagulation factors and lower pH. Chilled platelets have a higher hemostatic efficiency and a longer shelf life. Whole blood maximizes the effectiveness of circulatory resuscitation from the start in an optimal ratio.[1]