A 58-year-old man with pancreatic cancer underwent ERCP with placement of a fully covered self-expanding metal stent for obstructive jaundice, after which bilirubin decreased significantly. On the 10th postoperative day, the patient developed fever and severe abdominal pain in the right upper quadrant. Enhanced computed tomography confirmed perforation of the gallbladder complicated by the formation of a pericholecystic abscess. Ultrasound-guided percutaneous drainage of the abscess and repeat ERCP with plastic stent replacement of the common bile duct resolved the complication. This is the first reported case of gallbladder perforation after ERCP in a pancreatic cancer patient. Advanced imaging methods such as enhanced CT play a key role in identifying ERCP complications. This case emphasizes the need for a thorough postoperative examination, especially for relevant symptoms.