Cancer control is not a one-time event, but must become a lifelong system. Cancer is a multi-disease caused by various factors that act synergistically over many years[1]. CDC uses a comprehensive framework for chronic disease prevention involving four strategies: epidemiology and surveillance, environmental approaches, health systems interventions, and community-clinical linkages[1]. The Division of Cancer Prevention and Control (DCPC) has historically focused on cancer screening and registries, but is now investigating all four strategies for primary cancer prevention[1]. The Cancer Prevention Across the Lifespan (CPAL) Task Force supports innovative public health approaches to cancer prevention tailored to different age stages based on a socio-ecological framework[1]. The lifecourse approach in cancer research examines biological, environmental, behavioral and social factors across the lifespan, including critical periods and accumulation of exposures[4]. Screening tests can extend life by about 3 months with colorectal screening by sigmoidoscopy, according to a meta-analysis of 18 randomized trials with 2,111,958 participants[3]. DCPC will continue to support partnerships, research translation and dissemination of effective cancer prevention strategies across the lifespan[1].