The study examined serum levels of the adipokines omentin and chemerin in 40 hospitalized patients with COVID-19 and 24 healthy controls. Chemerin and omentin are substances secreted mainly by visceral adipose tissue with pro-inflammatory and anti-inflammatory effects. Patients with COVID-19 had significantly higher inflammatory markers such as C-reactive protein, ferritin, interleukin-6, and D-dimer compared to controls. Baseline omentin levels did not differ between patients (363.6 [245.2–513.0] ng/ml) and controls (368.9 [254.1–468.8] ng/ml; p=0.994) and remained stable until day 7 (p=0.60). Conversely, chemerin levels were significantly higher in patients at day 0 (234.3 [164.9–269.9] ng/ml vs. 144.7 [98.0–213.2] ng/ml in controls; p=0.001) and remained elevated at day 7 (243.7–376.9 ng/ml; p=0.001 vs. controls), with a trend toward a slight increase (+42.6 ng/ml; p=0.071). The findings suggest a role for chemerin, not omentin, in the systemic inflammatory response to SARS-CoV-2.