A qualitative study explored the experiences of heart failure patients in a home telemedicine program through 21 semi-structured interviews where data saturation was achieved. Five main categories were identified: telemedicine benefits (perceived safety and reassurance, greater self-control, telemedicine referral); impact on everyday life (time impact, practical limitations and mobility, conflicting experiences); relationship with healthcare workers (attendance, desire for more contact, professional behavior); interaction with technology (unreliable devices, unreliable connectivity); and family context (family support, attitudes of family members). Telemedicine improves perceived safety, self-monitoring, continuity of care, and treatment adherence when supported by strong physician relationships, reliable technology, and alignment with routines and family. Future programs should be designed with patients and caregivers in mind, with flexible monitoring, data interpretation, and two-way communication. Multicenter, mixed methods studies are needed to refine patient-centered models.