The study compared three lymph node removal strategies in laparoscopic colon cancer surgery: D1 (reduced), D2 (standard), and D3 (extended). Five-year patient survival was highest in the D3 group at 82%, followed by D2 at 75% and D1 at 65%. The D3 group also had the lowest rate of disease recurrence – just 8% compared to 12% for D2 and 18% for D1. However, extended D3 dissection was associated with a higher complication rate—35% compared with 25% for D2 and 15% for D1. The quality of life after surgery was the lowest in the D3 group, especially in the area of mobility and self-care. The choice of strategy should be individualized based on the patient's risk factors, with D3 being appropriate for high-risk patients, D2 offering a balanced approach, and D1 may be sufficient for low-risk cases.