Sialorrhea is a common non-motor symptom of Parkinson's disease that worsens swallowing and speech problems, causes perioral dermatitis, choking, aspiration pneumonia, social embarrassment, and psychiatric problems such as sadness or anxiety. The study developed a structured nursing program for the management of sialorrhea based on symptom management theory (SMT) through two rounds of expert Delphi consultations, with 13 secondary, 39 tertiary and three primary indicators. In a pilot randomized controlled trial, 80 patients with sialorrhea in Parkinson's disease were included, randomized to intervention and control groups. After four weeks, the intervention group scored significantly lower on the Parkinson's Disease Clinical sialorrhea scale and the sialorrhea-related items of the Unified Parkinson's Disease Rating Scale than the control group (P < 0.05). The intervention group also had a significantly higher score in self-management ability (P < 0.05). The program provides preliminary evidence of feasibility and effectiveness in reducing symptom severity and improving self-management. Registered as ChiCTR2500096034.