The US Department of Energy launched the Genesis Mission, a national initiative to transform science and innovation through artificial intelligence (AI), with the goal of doubling the productivity of American science and engineering within ten years[2][9]. The initiative mobilizes 17 DOE national laboratories, industry, and academia to create an integrated platform linked by supercomputers, experimental facilities, and data[3][6]. DOE has announced 26 energy and homeland security AI challenges, including accelerating the design, licensing and operation of nuclear reactors to at least double timelines and reduce operating costs by more than 50 percent[1][4]. Challenges include using explainable AI, surrogate models, agent workflows, autonomous laboratories, and digital twins to accelerate reactor deployment, grid modernization, and integration of large loads like data centers[1][4]. Areas such as fusion, particle accelerators, quantum technologies and national security are also supported[2][3]. DOE has earmarked $293 million in funding for interdisciplinary teams from laboratories, the private sector, and universities to address these challenges in advanced manufacturing, biotechnology, nuclear energy, and quantum computing.[5][7] Google DeepMind will give national labs access to AI models like Gemini to generate hypotheses and accelerate discoveries[3].