CD147 is a transmembrane glycoprotein found in tissues and plays an important role during pregnancy. During normal pregnancy, CD147 regulates the expression of matrix metalloproteinases, promotes the formation of new blood vessels (angiogenesis) and participates in the implantation of the embryo and the development of the placenta. The protein also helps create an immune environment between mother and fetus and affects placental metabolism. In pathological pregnancies, the expression of CD147 is disturbed - its reduction is associated with preeclampsia, repeated failure of implantation and restriction of fetal growth. Conversely, increased expression of CD147 may promote abnormal tissue invasion in gestational choriocarcinoma and placenta accreta. CD147 exhibits a "dual regulatory" characteristic, meaning that its proper level is critical for a healthy pregnancy. The research suggests that CD147 has the potential to serve as a biomarker for diagnosing obstetric complications and as a target for future therapies.