Age-related macular degeneration (AMD) is the leading cause of vision loss in the elderly, and its pathophysiology is incompletely understood. The study evaluated the protective effects of Qiju Granule in a mouse model of AMD induced by chronic light exposure and hydroquinone feeding. Retinal function and structure were assessed by electroretinography and histomorphological analyses. Qiju Granule treatment preserved retinal function, improved electroretinographic responses, and maintained the structural integrity of the retina and RPE layer. Qiju Granule showed anti-apoptotic effects with significant reduction of TUNEL-positive retinal cells. It reduced the expression of the angiogenic factors VEGF and CD31, thereby suppressing aberrant angiogenic signaling. The findings suggest a protective role for Qiju Granule in mitigating retinal damage and its potential as a therapeutic candidate for the prevention of advanced AMD.