The study describes the nursing care of a patient with a 23-year history of syringomyelia complicated by bacterial pneumonia and a severe pressure injury. The main goals were to control infections and correct malnutrition. Comprehensive interventions combining Chinese and Western medicine aimed at prevention of respiratory infections, pressure injuries and nutritional support were implemented. Multidisciplinary management included appropriate antibiotic therapy and pressure injury care. After 13 days of hospitalization, the patient's condition stabilized, the fever decreased, the markers of infection decreased, and there were no secondary infections. The patient was successfully discharged and subsequently followed up. The case highlights the challenges of multiple comorbidities and the need for multidisciplinary collaboration. It provides guidelines for improving the quality of care for similar patients.