A study examined kinesiophobia (excessive fear of movement) in 246 patients with psoriatic arthritis and found that this phobia was present in 45.5% of them. Patients with kinesiophobia showed significantly higher central sensitization scores (41.5 vs. 29), lower physical activity (1,619.5 vs. 2,970 MET minutes per week), and greater disease activity compared to patients without kinesiophobia. There was a significant correlation between kinesiophobia and central sensitization (r = 0.39). Central sensitization and sleep quality were shown to be independent predictors of kinesiophobia, which explained 12% of the variation in its occurrence. The study concluded that kinesiophobia acts as an amplifier of pain perception and functional disability, especially in patients with a mismatch between symptoms and inflammation. A bidirectional relationship between kinesiophobia and central sensitization likely maintains chronic pain and disability in these patients.