The new issue of JAMA contains articles from March 24, 2026, Volume 335, Number 12. One of the topics deals with antibiotic therapy in uncomplicated acute appendicitis and presents a ten-year follow-up of the APPAC randomized clinical trial. Also included is an editorial comment on this topic entitled "The Appendicitis Gamble—To Cut or to Keep". Another review focuses on type 1 diabetes mellitus. The issue also includes the Electronic Health Record (EHR) Intervention and Deprescription in Older Adults (NUDGE-EHR) study.