A 35-year-old pregnant woman after natural conception had low β-hCG levels at the beginning of pregnancy, which is related to abnormal development of placental villi. She received treatment with recombinant human granulocyte colony-stimulating factor, low-molecular-weight heparin, and dydrogesterone to maintain the pregnancy. From the 12th week of pregnancy she used aspirin 100 mg per day, in the 20th week the dose was increased to 150 mg due to significant edema. At 32+4 weeks of pregnancy, she developed severe preeclampsia caused by poor placental function. After precise individual treatment management, she achieved a good prognosis for both mother and child. Physicians should pay close attention to pregnant women with low β-hCG in early pregnancy and guide personalized treatment.