Minipuberty is a temporary activation of the hormonal system (HPG axis) during the neonatal period, which occurs mainly in the first 3-6 months of life of both sexes[1]. This activation causes an increase in hormone levels that allow the genitals to mature[1]. For boys, this activity is most pronounced in grades 2-3. months of life and ends around the 6th month, while in girls it can last until the 2nd-4th month. years of age[2]. Minipuberty provides an important diagnostic window for the early identification of disorders of sexual development, allowing prompt initiation of treatment instead of waiting for the failure of puberty[1]. Research suggests that hormones during the first five months of life influence boys' somatic development over the next six years[1]. Patients with congenital disorders (such as GnRH hormone deficiency) lack minipuberty, leading to testicular immaturity and a lower number of Sertolli cells important for future fertility[3]. Hormone replacement to mimic minipuberty in boys with these disorders can have positive effects on testicular initiation and normalization of their size[2].