A retrospective cohort study investigated the risk of missing aggressive appendiceal tumors in patients with acute appendicitis treated exclusively with antibiotics. The risk of such tumors was very low. The study analyzed 2,293 cases of appendectomies. Among them, 1.6% of cases had a malignant or premalignant finding. These findings suggest that antibiotic treatment alone rarely results in tumors being missed. The study was published on MedPage Today.