This study examined the treatment of infected diabetic foot ulcers in 300 patients between 2020-2024. Severity of infection was graded according to the IWGDF/IDSA scale. Higher levels of infection were correlated with poorer glycemic control, higher prevalence of peripheral artery disease, and changes in microbial composition. Healing time was prolonged and amputation rates increased with increasing severity of infection. A nomogram was created to predict the risk of nonunion, which took into account the degree of infection, presence of peripheral artery disease, HbA1c value, and revascularization status. The nomogram demonstrated good accuracy and calibration in predicting risk. The study confirmed that the IWGDF/IDSA classification effectively stratifies patients and the nomogram can help in individualized risk prediction.