The study evaluated the cost-effectiveness of using oxygen mixers (OME) to prevent retinopathy of prematurity (ROP) in Uganda. OMEs have been found to reduce the incidence of severe ROP, which can lead to visual impairment. The cost of preventing one case of severe visual impairment from ROP ranges from $25.55 to $543.99. The use of OME results in disability-adjusted life years (DALYs) averted, with an estimated cost of $4.97–$104.98 per DALY averted. Compared to malaria prevention, OME is considered a cost-effective way to prevent severe visual impairment in children in Uganda. The baseline cost estimate per DALY averted is $32.60. The implementation of OME represents an ethical and humanitarian benefit.