The current outbreak of Ebola virus disease, caused by the Bundibugyo virus, is affecting the Democratic Republic of Congo (DR Congo) and Uganda. This situation represents not only a biomedical emergency but also a test for global health diplomacy in a conflict zone. The World Health Organization (WHO) has declared this event a Public Health Emergency of International Concern. This declaration was prompted by several factors. These include insecurity, high population mobility, infections among health-care workers, and uncertainty regarding the extent of virus transmission. The situation in DR Congo requires urgent attention and coordinated efforts.