[Articles] Safety and efficacy of decompressive craniectomy versus standard craniotomy for large acute epidural haematoma with tentorial herniation in China (PREDICT-AEDH): a nationwide, multicentre, open-label, parallel-group, randomised controlled trial

The PREDICT-AEDH study was a randomized controlled trial conducted in China comparing decompressive craniectomy with standard craniotomy in patients with large acute epidural haematoma and tentorial herniation. The results showed that decompressive craniectomy did not improve functional outcomes in patients at six months compared to standard craniotomy. Additionally, decompressive craniectomy increased the risk of delayed intracranial haemorrhage. Based on these findings, the study does not recommend routine prophylactic decompressive craniectomy in this patient population. The study was multicentre and open-label.