Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinson's disease

The study examined deep brain stimulation (DBS) of the subthalamic nucleus in four Parkinson's disease patients. Researchers measured electrical activity in the motor cortex and subthalamic nucleus during various stimulation parameters at rest and during finger-tapping movements. They found that the amplitude of stimulation-induced gamma oscillations was non-linearly dependent on stimulation intensity and frequency. Gamma synchronization in the precentral gyrus was associated with reduced bradykinesia, dyskinesia, and dystonia in medicated patients. The results suggest that stimulation-induced gamma oscillations in the motor network serve as a marker of optimal DBS response and could be used for individualized DBS programming.