Insect bites are not always trivial matters. Most reactions are mild with local swelling, pain, and itching that resolve within hours. However, approximately one-quarter of people may experience a more severe reaction with swelling exceeding 10 centimeters lasting longer than 24 hours. The most serious are systemic allergic reactions leading to anaphylactic shock, which typically occurs in allergic individuals within 15 minutes of the bite. Symptoms of anaphylaxis include shortness of breath, facial and throat swelling, accelerated pulse, blood pressure drop, dizziness, and nausea. Immediate medical attention with epinephrine administration is necessary when allergic reaction is suspected. In 2025, 18,520 VZP clients were treated for insect bites, with treatment costs exceeding 18 million crowns.