The study examines the application of bundle nursing intervention in intensive care units (ICUs). The interventions include routine ICU nursing care, prevention and control of healthcare-associated infections, and interdisciplinary collaboration. The program also encompasses prevention of specific complications including catheter-associated urinary tract infections (CAUTI), ventilator-associated pneumonia (VAP), and central line-associated bloodstream infections (CLABSI). The program includes real-time and precise patient monitoring and an interdisciplinary collaboration mechanism aimed at efficiency and coordination. The study was conducted at the First Hospital of Qinhuangdao and aimed to analyze the effectiveness of this comprehensive nursing intervention.