Guinea worm disease, also known as dracunculiasis, is a tropical disease caused by the parasite Dracunculus medinensis, transmitted through drinking water contaminated with infected copepods. People become infected when they consume water with parasite larvae, which penetrate the digestive tract and develop in the body for approximately one year. When the adult worm reaches the skin, it causes a painful blister and ulcer. Infected individuals seeking relief immerse the affected body part in water, triggering larval release and further water contamination. During worm emergence, patients experience intense pain, ulcer formation, and allergic reactions. Potential long-term complications include chronic inflammation, pain, and in severe cases, disability from joint damage. Thanks to the work of President Jimmy Carter and The Carter Center, this centuries-old disease may soon be added to the list of globally eradicated diseases.