Impact of kimura-takemoto atrophy classification on first-line H. pylori eradication: a retrospective cohort study

The study examined whether the endoscopic grade of gastric atrophy according to Kimura-Takemoto classification affects the success of H. pylori infection treatment. A total of 154 patients with confirmed H. pylori infection and chronic atrophic gastritis who received standard bismuth-containing therapy were analyzed. The overall eradication rate was 76.6 percent. Patients with open-type atrophy had significantly lower treatment success (42.3 percent) compared to closed-type atrophy (83.6 percent). The analysis confirmed that open-type atrophy is independently associated with treatment failure. The study recommends caution when using standard therapy in patients with open-type atrophy and suggests alternative treatment regimens without clarithromycin instead.