Ozempic changed obesity treatment, but experts say the real revolution is next

Weight-loss medications such as Ozempic and Zepbound (containing semaglutide and tirzepatide) have dramatically changed obesity treatment in the United States. However, experts emphasize that these drugs are only one part of managing this complex chronic disease. The updated POWER framework from 2026 proposes a combined approach integrating medications, endoscopic procedures, bariatric surgery, and personalized medicine based on genetic factors. Research shows that combining GLP-1 medications with endoscopic procedures or surgery can lead to greater weight loss and longer-lasting results. Gastroenterologists and hepatologists play an important role in treating obesity and its complications, including liver disease, reflux, and various gastrointestinal problems.