The PROTEUS trial presents promising results in the field of prostate cancer treatment. It focuses on perioperative therapy, which is administered before and/or after surgical intervention. Specifically, it involves a combination of androgen-deprivation therapy (ADT) with the drug apalutamide. This combination could represent a new treatment option. It is intended for patients with high-risk, localized prostate cancer. The aim is to improve treatment outcomes for this patient group. If its efficacy is confirmed, this therapy could change standard procedures. It represents a significant advancement in the search for more effective methods to combat this disease.