Evaluation of CD16, CD32, CD40, and CD152 polymorphisms in immune thrombocytopenia patients: a systematic review, meta-analysis, and trial sequential analysis

The study examined genetic polymorphisms of CD16, CD32, CD40, and CD152 genes in immune thrombocytopenia (ITP) patients through a systematic review and meta-analysis of 33 articles. Researchers found a significant association between the FcγRIIIA-158 F/V polymorphism and ITP susceptibility, with the highest value of 2.61 in the homozygous model. Other examined polymorphisms (FcγRIIA-131 H/R, FcγRIIB-232 I/T, CTLA-4 exon 1 A49G, CTLA-4 CT60, CD40 rs4810485, and CD40 rs1883832) showed no significant associations with the disease. Heterogeneity between studies was highest in the heterozygous model of FcγRIIA-131 H/R (69%) and the dominant model of CTLA-4 CT60 (80%). The researchers concluded that the FcγRIIIA-158 F/V polymorphism is consistently associated with disease susceptibility and that further research is needed to validate other findings.