This network meta-analysis addresses an important topic in medicine. Its goal is to examine the adverse effects of blood pressure-lowering drugs. Concurrently, it investigates the reasons and frequency of treatment discontinuation with these medications. The analysis focuses on short-term randomized clinical trials. It evaluates various drug classes and their combinations. It also examines different treatment regimens. The aim is to provide a comprehensive overview of the safety and tolerability of these therapies. This can help physicians in selecting the most appropriate treatment for patients with high blood pressure.