The article discusses strategies for lifestyle modifications and management of adverse effects in individuals with obesity receiving incretin-based therapy for weight loss. Incretin-based therapies are medications that help regulate blood sugar levels and promote weight reduction. Lifestyle changes, including modifications in diet and physical activity, are an important part of obesity treatment. The article emphasizes the need to manage side effects that may occur when using these medications. The combination of pharmacological treatment and lifestyle modification is considered an effective approach to obesity management. The goal is to provide a comprehensive approach to managing obesity and improving patients' health status.