Catheter ablation is a minimally invasive surgical procedure used to treat persistent atrial fibrillation, a type of heart arrhythmia. The procedure involves inserting a catheter through blood vessels into the heart to destroy tissue causing abnormal electrical signals. This procedure is performed under specialized imaging and electrophysiological monitoring. Catheter ablation is indicated for patients in whom pharmacological treatment was not sufficiently effective or was not tolerated. Research published in the New England Journal of Medicine in June 2026 addresses the efficacy and safety of this method. The procedure may reduce symptoms and improve quality of life in patients with persistent atrial fibrillation.