PPP-COMPUTE: A Pandemic Pharmacology Platform for COMPUTational Evaluation of Anti-infectives in Pandemic Preparedness

PPP-COMPUTE is a comprehensive computational platform designed to support the evaluation and prioritization of drug candidates during pandemics. The platform combines experimentally derived anti-infective potency data (such as EC50) with pharmacokinetic-pharmacodynamic modeling to determine whether clinical dosing can achieve sufficient exposure for therapeutic efficacy in patients. The system incorporates mechanism-based dynamic models focused on viral pathogens that simulate time-dependent viral load trajectories under various treatment scenarios. The platform further includes probability of target attainment analyses and a clinical module for generating simulated virological endpoints. PPP-COMPUTE represents an accessible and quantitative framework that links pharmacokinetic and preclinical anti-infective data with predicted clinical benefit.