Your brain may be wired to regain lost weight

Weight loss is not merely a test of willpower, as the human brain evolved to protect body fat during times of food scarcity. The brain can perceive a previously higher weight as the body's new normal. After weight loss, this triggers stronger hunger, cravings, and reduced energy expenditure. This biological "memory" helps explain why many people regain weight after dieting. Medications such as Wegovy and Mounjaro can assist by reducing appetite signals. However, their effects may diminish once treatment is discontinued.