The SOLARIS study investigated the addition of high-dose vitamin D3 to standard treatment in patients with metastatic colorectal cancer. This was a randomized clinical trial led by Dr. Kimmie Ng and Dr. Fang-Shu Ou. The research was published in August 2026 in JAMA as an original investigation. The objective was to determine whether high-dose vitamin D3 could improve treatment outcomes in patients with advanced colorectal cancer. The study represents part of a comprehensive Alliance research program aimed at improving cancer treatment. The results of this trial contribute to understanding the potential role of vitamin D3 in oncological therapy.