Prostaglandins prevent long-lasting pain in a mouse model of chronic postsurgical pain: reconciling animal and clinical evidence. Response to Br J Anaesth 2026; 137: 344–6

This article is a response to a comment on a previous scientific paper. It explores the role of prostaglandins in preventing long-lasting pain in a mouse model of chronic postsurgical pain. The authors agree that proof-of-concept biology and clinical decision-making are complementary but not interchangeable. They emphasize that their findings should not be immediately interpreted as a recommendation to change current perioperative nonsteroidal anti-inflammatory drug (NSAID) use. The research focuses on the potential of prostaglandins in preventing chronic pain after surgery. The authors express satisfaction that their discovery has generated a much-needed discussion on the use of anti-inflammatory drugs in the postoperative setting.