The study addresses the optimal timing of percutaneous coronary intervention (PCI) in patients undergoing transcatheter aortic valve implantation (TAVI). TAVI is a minimally invasive procedure for replacing a damaged aortic valve without surgical opening of the chest. Many patients have concurrent coronary artery narrowing that requires PCI. The article examines whether it is better to perform PCI before TAVI, during TAVI, or after TAVI. The research published in the New England Journal of Medicine provides important insights for clinical practice in treating patients with multiple cardiac conditions. Proper timing of these procedures is crucial for the safety and efficacy of treatment.