George Washington contracted smallpox during his stay in Barbados in 1751 in his youth, which left him with minor facial scars. This personal experience later influenced his decisions regarding the health of his troops. Variolation, a procedure introduced in the New World by Puritan minister Cotton Mather in 1721, was an effective prevention method with lower mortality than natural infection. While natural smallpox had a mortality rate of 25-30 percent, variolation reduced mortality to 1.5-2.6 percent. Initially, Washington prohibited routine variolation in the Continental Army in 1776 for tactical reasons, as it would temporarily reduce troop readiness. However, he later reversed his position when smallpox epidemics threatened greater losses. Washington's evolving stance on variolation reflected his respect for medical innovation and military necessity.