Age-stratified correlations between atopic dermatitis severity and biomarkers: hypercoagulability as a key indicator of severity in older adults

The study examined the relationship between atopic dermatitis (AD) severity and various biomarkers in 181 AD patients and 101 healthy controls. All measured biomarkers were significantly higher in AD patients. Total IgE, systemic immune-inflammation index, and platelet-to-lymphocyte ratio positively correlated with disease severity independent of age. In patients older than 60 years, D-dimer proved to be the best predictive marker for moderate-to-severe AD with accuracy of 0.805. In younger patients (under 60 years), the D-dimer-to-fibrinogen ratio was a better marker with accuracy of 0.723. Results indicate that AD patients have systemic inflammatory processes and subclinical hypercoagulability. The authors recommend an age-stratified clinical approach with measurement of specific biomarkers depending on patient age.