The ADVOCATE initiative focuses on patients with heart failure. Its aim is to explore how autonomous AI agents could assist these patients. This topic was discussed on the JAMA+ AI Conversations podcast. Among the discussants was Roy Perlis, MD, MSc, Editor in Chief of JAMA+ AI. Another participant was Haider Warraich, MD, a cardiologist. Dr. Warraich also serves as a program manager at ARPA-H. The conversation centered on the potential of artificial intelligence in the care of heart failure patients.