Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke

The article discusses a study examining the use of intra-arterial alteplase as adjunctive therapy following successful thrombectomy in patients with acute ischemic stroke caused by large vessel occlusion. The research team found that this combined treatment may improve functional recovery in patients. The study represents an important test of this reperfusion strategy aimed at restoring blood flow to the brain. However, the authors highlight a significant concern - the main study findings were based on a primary outcome measure that was changed during the course of the trial. This modification raises questions about the reliability and interpretation of the obtained results.