The study focused on adapting and validating TabCAT (Tablet-based Cognitive Assessment Tool) - a digital platform for cognitive testing - in Uganda. The research included 563 participants with a mean age of 60 years, of which 49% were living with HIV and 51% had not completed primary school. The tool was translated and culturally adapted through expert reviews and focus group discussions. TabCAT tests demonstrated good validity in discriminating cognitive impairment with a c-statistic of 0.77 (95% CI 0.72-0.81), including among people living with HIV. Results showed that tablet-based testing is suitable for measuring cognitive performance even in individuals with lower education and literacy levels. The tool could be useful for detecting dementias in sub-Saharan Africa.